THE DEFINITIVE GUIDE TO PKRRATING

The interfacial residues are remarkably conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model exactly where activating RNA serves as a scaffold to bind a number of PKR monomers, raising

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